PUBLICATIONS

Ruffenach G, O'Connor E, Vaillancourt M, Hong J, Cao N, Sarji S, Moazeni S, Papesh J, Grijalva V, Cunningham CM, Shu L, Chattopadhyay A, Tiwari S, Mercier O, Perros F, Umar S, Yang X, Gomes AV, Fogelman AM, Reddy ST, Eghbali M. (2020) Oral 15-Hydroxyeicosatetraenoic Acid Induces Pulmonary Hypertension in Mice by Triggering T Cell-Dependent Endothelial Cell Apoptosis. Hypertension.120.14697.

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Wagner KM, Gomes A, McReynolds CB, Hammock BD. (2020) Soluble Epoxide Hydrolase Regulation of Lipid Mediators Limits Pain. Neurotherapeutics. 2020 Jul;17(3):900-916.

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2019

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Kazmierczak K, Liang J, Yuan CC, Yadav S, Sitbon YH, Walz K, Ma W, Irving TC, Cheah JX, Gomes AV, Szczesna-Cordary D. (2019) Slow-twitch skeletal muscle defects accompany cardiac dysfunction in transgenic mice with a mutation in the myosin regulatory light chain. FASEB J.33:3152-3166.

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Mishra M, Tiwari S, Gunaseelan A, Li D, Hammock BD, Gomes AV. (2019) Improving the sensitivity of traditional Western blotting via Streptavidin containing Poly-horseradish peroxidase (PolyHRP). Electrophoresis. 40(12-13): 1731-1739.

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Sander H, Wallace S, Plouse R, Tiwari S, Gomes AV. (2019) Ponceau S waste: Ponceau S staining for total protein normalization. Anal Biochem. 575: 44-53.

 

Hwang HV, Lin Y, Rebuffatti MN, Tran DT, Lee L, Gomes AV, Li CS, Knowlton AA.(2019) Impaired Proteostasis in Senescent Vascular Endothelial Cells: A Perspective on Estrogen and Oxidative Stress in the Aging Vasculature. Am J Physiol Heart Circ Physiol. 316(2):H421-H429.

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2018

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Gomes AV. (2018) Spatiotemporal Multi-Omics-Derived Atlas of Calcific Aortic Valve Disease. Circulation. Jul 24;138(4):394-396

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Yuan CC, Kazmierczak K, Liang J, Zhou Z, Yadav S, Gomes AV, Irving TC, Szczesna-Cordary D. (2018) Sarcomeric perturbations of myosin motors lead to dilated cardiomyopathy in genetically modified MYL2 mice. Proceedings of the National Academy of Sciences of the United States of America. 2018; 115(10):E2338-E2347.

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Yuan CC, Kazmierczak K, Liang J, Kanashiro-Takeuchi R, Irving TC, Gomes AV, Wang Y, Burghardt TP, Szczesna-Cordary D. (2017) Hypercontractile mutant of ventricular myosin essential light chain leads to disruption of sarcomeric structure and function and results in restrictive cardiomyopathy in mice. Cardiovascular Research. 113(10):1124-1136.

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2017

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Inceoglu B, Bettaieb A, Haj FG, Gomes AV, Hammock BD. (2017) Modulation of mitochondrial dysfunction and endoplasmic reticulum stress are key mechanisms for the wide-ranging actions of epoxy fatty acids and soluble epoxide hydrolase inhibitors. Prostaglandins & other lipid mediators. 133:68-78.

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Mishra M, Tiwari S, Gomes AV. (2017) Protein purification and analysis: next generation Western blotting techniques. Expert review of proteomics. 14(11):1037-1053.

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Gilda JE, Gomes AV. (2017) Proteasome dysfunction in cardiomyopathies. The Journal of physiology. 595(12):4051-4071.

Wagner K, Gilda J, Yang J, Wan D, Morisseau C, Gomes AV, Hammock BD. (2017) Soluble epoxide hydrolase inhibition alleviates neuropathy in Akita (Ins2 Akita) mice.Behavioural brain research.  326:69-76.

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2016

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Gilda, J.E., Lai, X., Witzmann, F.A., Gomes, A.V. (2016) Delineation of molecular pathways involved in cardiomyopathies caused by troponin T mutations. Mol. Cell. Proteomics. 15(6):1962-81.

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Nguyen S, Siu R, Dewey S, Cui Z, Gomes AV. (2016) Amino Acid Changes at Arginine 204 of Troponin I Result in Increased Calcium Sensitivity of Force Development. Frontiers in physiology. 2016; 7:520.

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Ghosh., R., Goswami, S.K., Feitoza, L.F.B.B., Hammock, B., Gomes AV  (2016) Diclofenac induces proteasome and mitochondrial dysfunction in murine cardiomyocytes and hearts. International Journal of Cardiology. 2016; 223:923-935.

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Ghosh., R., Hwang, S.M, Cui, Z., Gilda, J.E., Gomes A.V. (2016) Different effects of the nonsteroidal anti-inflammatory drugs meclofenamate sodium and naproxen sodium on proteasome activity in cardiac cells. J Mol Cell Cardiol.  94:131-144.

Landry M, Gomes AV. (2016) Antibodies: Half of samples fail protein-blot tests. Nature. 529(7584):25.

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Gilda JE, Xu Q, Martinez ME, Nguyen ST, Chase PB, Gomes AV. (2016) The functional significance of the last 5 residues of the C-terminus of cardiac troponin I. Arch Biochem Biophys. 601:88-96. 

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Gilda, JE, Lai, X, Witzmann, FA, Gomes, AV. (2016) Delineation of Molecular Pathways Involved in Cardiomyopathies Caused by Troponin T Mutations.  Mol Cell Proteomics. Jun;15(6):1962-81.

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Klionsky DJ, et al. (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12(1):1-222. 

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West DW, Baehr LM, Marcotte GR, Chason CM, Tolento L, Gomes AV. Baar, K. (2016) Acute resistance exercise activates rapamycin-sensitive and -insensitive mechanisms that control translational activity and capacity in skeletal muscle. J Physiol. 2016 Jan 15;594(2):453-68. 

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2015

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Ghosh, R., Alajbegovic, A., Gomes, A.V. (2015) NSAIDs and Cardiovascular Diseases: Role of Reactive Oxygen Species.  Oxidative Medicine and Cellular Longevity. 2015;2015:536962

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Gomes AV, Rajasekaran NS, Pi X. (2015) Redox Signaling and the Cardiovascular and Skeletal Muscle System. Oxid Med Cell Longev. 2015:849095.

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Carbonell T, Gomes AV. (2015) Dynamic regulation of the proteasome by systolic overload. J Mol Cell Cardiol. 87:1-3.

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Gomes AV, Kazmierczak K, Cheah JX, Gilda JE, Yuan CC, Zhou Z, Szczesna-Cordary D. (2015) Proteomic analysis of physiological versus pathological cardiac remodeling in animal models expressing mutations in myosin essential light chains.J Muscle Res Cell Motil. 36(6):447-61. 

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Negroni JA, Morotti S, Lascano EC, Gomes AV, Grandi E, Puglisi JL, Bers DM. (2015) Modeling beta-adrenergic effects on cardiac contraction-relaxation in an integrated rabbit ventricular myocyte model. Journal of Molecular and Cellular Cardiology. 81:162-175.

 

Lindsey ML, Mayr M, Gomes AV, Delles C, Arrell DK, Murphy AM, Lange RA, Costello CE, Jin YF, Laskowitz DT, Sam F, Terzic A, Van Eyk J, Srinivas PR Transformative Impact of Proteomics on Cardiovascular Health and Disease: A Scientific Statement From the American Heart Association.Circulation. 2015 Sep 1;132(9):852-72. 

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Gilda JE, Ghosh R, Cheah JX, West TM, Bodine SC, Gomes AV. (2015) Western Blotting Inaccuracies with Unverified Antibodies: Need for a Western Blotting Minimal Reporting Standard (WBMRS). PLoS One. 19;10(8):e0135392. 

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Gilda JE, Gomes AV. (2015) Western blotting using in-gel protein labeling as a normalization control: stain-free technology. Methods Mol Biol. 1295:381-91

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2014

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Puglisi JL, Goldspink PH, Gomes AV, Utter MS, Bers DM, Solaro RJ. (2014) Influence of a constitutive increase in myofilament Ca2+-sensitivity on Ca(2+)-fluxes and contraction of mouse heart ventricular myocytes. Arch Biochem Biophys. 15;552-553:50-9.

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Cui, Z, Hwang, S.M, Gomes AV. (2014) Identification of the Immunoproteasome as a Novel Regulator of Skeletal Muscle Differentiation.Mol Cell Biol. 34:96-109.

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Cui Z, Gilda JE, Gomes AV. (2014) Crude and purified proteasome activity assays are affected by type of microplate. Anal Biochem. 446:44-52.

 

Narashimhan M., Hong J., Atieno N., Muthusamy V.R., Davidson C.J., Abu-Rmaileh N., Richardson R., Gomes A.V., Hoidal J.R., Rajasekaran N.S. (2014) Nrf2 Deficiency Promotes Apoptosis and Impairs Pax7/MyoD Expression in Aging Skeletal Muscle Cells. Free Radical Biology and Medicine. 71:402-14.

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Wecksler, A.T., Hwang, S.H., Wettersten, H.I., Gilda, J.E., Gomes, A.V., Baar, K., Patton, A., Weiss, R.H., Hammock, B.D. (2014) Novel sorafenib-based structural analogues: in-vitro anticancer evaluation of t-MTUCB and t-AUCMB. Anticancer Drugs 25(4):433-46.

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Jamart, C., Gomes, A.V., Dewey, S., Deldicque, L., Raymackers, L.D., Francaux, M. (2014) Regulation of ubiquitin-proteasome and Regulation of ubiquitin-proteasome and autophagy pathways after acute LPS and epoxomicin administration in mice. BMC Musculoskelet Disord.15:166.

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Domenighetti AA, Chu PH, Wu T, Sheikh F, Gokhin DS, Guo LT, Cui Z, Peter AK, Christodoulou DC, Parfenov MG, Gorham JM, Li DY, Banerjee I, Lai X, Witzmann FA, Seidman CE, Seidman JG, Gomes AV, Shelton GD, Lieber RL, Chen J. (2014) Loss of FHL1 induces an age-dependent skeletal muscle myopathy associated with myofibrillar and intermyofibrillar disorganization in mice. Hum Mol Genet. 23;209-225.

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Cui Z, Scruggs SB, Gilda JE, Ping P, Gomes AV. (2014) Regulation of Cardiac Proteasomes by Ubiquitination, SUMOylation, and Beyond. J Mol Cell Cardiol. 71:32-42.

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Ghosh R, Gilda JE, Gomes AV. (2014) The necessity of and strategies for improving confidence in the accuracy of western blots. Expert Rev Proteomics. 11(5):549-60.

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2013

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Kannan S, Muthusamy VR, Whitehead KJ, Wang L, Gomes AV, Litwin SE, Kensler TW, Abel ED, Hoidal JR, Rajasekaran NS. (2013) Nrf2 deficiency prevents reductive stress-induced hypertrophic cardiomyopathy. Cardiovasc Res. ;100:63-73.

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Gilda JE, Gomes AV. (2013) Stain-Free total protein staining is a superior loading control to β-actin for Western blots. Anal Biochem.; 440:186-8.

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Rajagopalan V, Zhao M, Reddy S, Fajardo G, Wang X, Dewey S, Gomes AV, Bernstein D. (2013) Altered ubiquitin-proteasome signaling in right ventricular hypertrophy and failure. Am J Physiol Heart Circ Physiol. 305:H551-62.

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Gomes, A.V. (2013) Genetics of proteasome diseases. Scientifica. 2013:637629.

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Gilda JE, Gomes AV. (2013) How phosphorylated can it get? Cardiac myosin binding protein C phosphorylation in heart failure. J. Mol Cell Cardiol. 62:108-10.

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Dewey S, Lai X, Witzmann FA, Sohal M, Gomes AV. (2013) Proteomic analysis of hearts from akita mice suggests that increases in soluble epoxide hydrolase and antioxidative programming are key changes in early stages of diabetic cardiomyopathy. J Proteome Res. ;12:3920-33.

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Boggess MV, Lippolis JD, Hurkman WJ, Fagerquist CK, Briggs SP, Gomes AV, Righetti PG, Bala K. (2013) The need for agriculture phenotyping: "Moving from genotype to phenotype" Journal of Proteomics. 93:20-39.

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Boggess MV, Lippolis JD, Hurkman WJ, Fagerquist CK, Briggs SP, Gomes AV, Righetti PG, Bala K. (2013) The need for agriculture phenotyping: "Moving from genotype to phenotype" J Proteomics. ii: S1874-3919(13)00168-1.

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2012

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Pinto, J.R., Gomes, A.V., Jones, M.A., Liang, J., Nguyen ,S., Miller, T., Parvatiyar, M.S,. Potter J.D. (2012) The functional properties of human slow skeletal troponin T isoforms in cardiac muscle regulation.  J Biol Chem.  287:37362-70.

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Gomes AV, Waddell DS, Siu R, Stein M, Dewey S, Furlow JD, Bodine SC. (2012) Upregulation of proteasome activity in muscle RING finger 1-null mice following denervation.  FASEB J. 26:2986-99.

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Iorga, A., Dewey, S., Partow-Navid1, R., Gomes AV,  Mansoureh, E. (2012) Pregnancy Is Associated with Decreased Cardiac Proteasome Activity and Oxidative Stress in Mice. PLOS One ;7(11):e48601.

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Xu, Q., Cui, Z., Venkatraman, G., Gomes AV (2012) The use of biophysical proteomic techniques in advancing our understanding of diseases. Biophysical Reviews 4, 125-135.

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2000-2011

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Cui, Z., Dewey, S., Gomes, A.V. (2011) Cardioproteomics: advancing the discovery of signaling mechanisms involved in cardiovascular diseases. Am. J. Cardiovasc. Dis. 1: 274-292.

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Hwee, D.T., Gomes, A.V., Bodine, S.C. (2011) Cardiac Proteasome Activity in Muscle Ring Finger-1 Null Mice at Rest and Following Synthetic Glucocorticoid Treatment. Am. J. Physiol. Endocrinol. Metab. 301: E967-77.

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Divald, A., Kivity, S., Wang, P., Hochhauser, E., Roberts, B., Teichberg, S., Gomes, A.V., Powell, S.R. (2010) Myocardial ischemic preconditioning preserves postischemic function of the 26S proteasome through diminished oxidative damage to 19S regulatory particle subunits. Circ Res. 106:1829-38.

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Xu, Q., Dewey, S., Nguyen, S., Gomes, A.V. (2010) Malignant and benign mutations in familial cardiomyopathies: insights into mutations linked to complex cardiovascular phenotypes J Mol Cell Cardiol. 48, 899-909.

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Dewey, S.,  Xu, Q., Gomes, A.V. (2010) Static and Dynamic Properties of the HCM  myocardium. J Mol Cell Cardiol. 49:715-8

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Tikunova, S.B., Liu, B., Swindle, N., Little, S.C., Gomes, A.V., Swartz, D.R., Davis, J.P. (2010) Effect of calcium-sensitizing mutations on calcium binding and exchange with troponin C in increasingly complex biochemical systems. Biochemistry. 49:1975-84.

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Willott, R.H., Gomes, A.V., Chang, A.N., Parvatiyar, M.S., Pinto, J.R., Potter, J.D. (2010) Mutations in Troponin that cause HCM, DCM AND RCM: what can we learn about thin filament function? J Mol Cell Cardiol. 48, 882-92. 

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Dewey, S., Gomes, A.V. (2010) Non-antigen processing immunoproteasomes in diabetic hearts? J Mol Cell Cardiol. 49:1-4.

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Gomes, A.V., Young, G.W., Wang, Y., Zong, C., Eghbali, M., Drews, O., Lu, H., Stefani, E., Ping, P. (2009) Contrasting proteome biology and functional heterogeneity of the 20S proteasome complexes in mammalian tissues. Mol. Cell Proteomics. 8:302-15.

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Mayr, M., Liem, D., Zhang, J, Li, X, Avliyakulov, N.K., Yang, J.I., Young, G, Vondriska, TM, Ladroue, C., Madhu, B., Griffiths, J.R., Gomes A., Xu, Q., Ping, P. (2009) Proteomic and metabolomic analysis of cardioprotection: Interplay between protein kinase C epsilon and delta in regulating glucose metabolism of murine hearts J. Mol. Cell. Cardiol. 46:268-77.

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Wen, Y., Pinto, J.R., Gomes, A.V., Xu, Y., Wang, Y, Wang, Y., Potter, J.D., Kerrick, W.G. (2008). Functional consequences of the human cardiac troponin I hypertrophic cardiomyopathy mutation R145G in transgenic mice. J. Biol Chem. 283, 20484-94.

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Lounes, K.C., Demeler, B., Anderson, D.E., Gomes, A.V., Potter, J.D., Nassar, R., Anderson, P.A. (2008) Cardiac troponin T forms a tetramer in vitro. Biochemistry. 47, 1970-6.

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Drews, O., Wildgruber, R., Zong, C., Sukop, U., Nissum, M., Weber, G., Gomes, A.V., Ping, P. (2007) Mammalian proteasome subpopulations with distinct molecular compositions and proteolytic activities. Mol. Cell. Proteomics 6:2021-2031.

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Gomes, A.V. Zong, C., Edmondson, R., Li, X., Stefani, E., Zhang, J., Jones, R.C., Thyparambil, S., Wang, G.W., Qiao, X., Bardag-Gorce, F., Ping, P. (2006) Mapping the Murine Cardiac 26S Proteasome Complexes. Circulation Research 99:362-71.

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Zong, C., Gomes, A.V. Drews, O., Li, X., Young, G.W., Berhane, B., Qiao, X., French, S.W., Bardag-Gorce, F., Ping, P. (2006) Regulation of Murine Cardiac 20S Proteasomes: Role of Associating Partners. Circulation Research 99:372-80.

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Gomes, A.V. Zong, C., Ping, P. (2006) Protein Degradation by the 26S Proteasome System in the Normal and Stressed Myocardium. Antioxidants & Redox Signaling 9/10:1677-1691.

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Gomes, A.V. et al., (2005) Murine Cardiac 26S Proteasome: An Organelle Awaiting Exploration. Ann N Y Acad Sci. 1047, 197-207.

Barnes, J.A, Singh, S., Gomes, A.V. (2005) Protease-activated receptors in cardiovascular function and disease. Mol. Cell Biochem. 263, 227-39.

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Gomes, A.V., Venkatraman, G., Potter, J.D. (2005) The miscommunicative cardiac cell: when good proteins go bad. Ann N Y Acad Sci. 1047, 30-7.

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Gomes, A.V., Liang, J., Potter J.D. (2005). Mutations in human cardiac troponin I that are associated with restrictive cardiomyopathy affect basal ATPase activity and the calcium sensitivity of force development. J. Biol Chem. 280, 30909-15.

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Gomes, A.V., Harada, K., Potter J.D. (2005). A Hypertrophic Cardiomyopathy Mutation in the N-terminal of Troponin I affects the Ca2+-Sensitivity, Phosphorylation Kinetics and Proteolytic Susceptibility of Troponin. J. Mol. Cell. Cardiol. 39, 754-65.

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Venkatraman, G., Gomes, A.V., Kerrick, W.G., Potter J.D. (2005) Characterization of troponin T dilated cardiomyopathy mutations in the fetal troponin isoform. J. Biol Chem. 280, 17584-92.

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Gomes, A.V., Venkatraman, G., Davis, J.P., Tikunova, S.B., Engel, P., Solaro, R.J., Potter J.D. (2004) Cardiac troponin T isoforms affect the Ca2+ sensitivity of force development in the presence of slow skeletal troponin I: Insights into the role of troponin T isoforms in the fetal heart. J. Biol Chem. 279, 49579-87.

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Gomes, A.V., Potter, J.D. (2004) Cellular and molecular aspects of familial hypertrophic cardiomyopathy caused by mutations in the cardiac troponin I gene. Mol Cell Biochem. 163, 99-114

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Gomes, A.V., Barnes, J.A., Harada, K., Potter, J.D. (2004) Role of troponin T in disease. Mol. Cell. Biochem. 263, 115-129

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Gomes, A.V., Potter, J.D. (2004) Molecular and cellular aspects of troponin cardiomyopathies. Ann N Y Acad Sci. 1015, 214-24.

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Yuan, T., Gomes, A.V., Barnes, J.A., Hunter, H.N. and Vogel, H.J. (2004) Spectroscopic characterization of the calmodulin-binding and autoinhibitory domains of calcium/calmodulin-dependent protein kinase I. Arch. Biochem. Biophys. 421, 192-206.

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Venkatraman, G., Harada K., Gomes, A.V., Kerrick, W.G., Potter, J.D. (2003) Different functional properties of troponin T mutants that cause dilated cardiomyopathy. J. Biol Chem. 278, 41670-6.

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Gutierrez-Ford, C., Levay, K., Gomes, A.V., Perera, E.M., Som, T., Kim, Y.M., Benovic J.L., Berkovitz G.D., Slepak V.Z. (2003)Characterization of Tescalcin, a Novel EF-Hand Protein with a Single Ca2+-Binding Site: Metal-Binding Properties, Localization in Tissues and Cells, and Effect on Calcineurin. Biochemistry 42, 14553-14565.

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Gomes, A.V., Guzman, G., Zhao, J., Potter, J.D. (2002) Cardiac troponin T isoforms affect the Ca2+-sensitivity and inhibition of force development: insights into the role of troponin T isoforms in the heart. J. Biol Chem. 277, 35341-35349.

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Lang, R., Gomes, A.V., Zhao, J., Housmans, P.R., Miller, T., Potter, J.D. (2002) Functional Analysis of a Troponin I (R145G) Mutation Associated with Familial Hypertrophic Cardiomyopathy. J. Biol. Chem. 277, 11670-11678.

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Barnes, J.A, Gomes, A.V. (2002) Proteolytic signals in the primary structure of annexins. Mol. Cell Biochem. 231, 1-7.

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Gomes, A.V., Keita, H., and Potter, J.D. (2002) Cation signaling in Striated Muscle Contraction. In Molecular Control Mechanisms in Striated Muscle Contraction Eds. Solaro, R.J., and Moss, R.L. Kluwer Academic Publishers, Netherlands, 163-197.

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Gomes, A.V., Potter, J.D., Szczesna, D. (2002) Role of Troponin in Muscle Contraction. IUBMB Life. 54, 323-333.

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Miller, T., Szczesna, D., Housmans, P.R., Zhao, J., de Freitas, F., Gomes, A.V., Culbreath, L., McCue, J., Wang, Y., Xu, Y., Kerrick, W.G. and Potter, J.D. (2001) Abnormal Contractile Function in Transgenic Mice Expressing an FHC-Linked Troponin T (I79N) Mutation. J. Biol. Chem. 276, 3743-3755.

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Szczesna, D., Ghosh, D., Li, Q., Gomes, A.V., Guzman, G., Arana, C., Zhi, G., Stull, J.T., Potter, J.D.(2001) Abnormal Familial hypertrophic cardiomyopathy mutations in the regulatory light chains of myosin affect their structure, Ca2+ binding and phosphorylation. J. Biol. Chem. 276, 7086-7092.

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Gomes A.V., Barnes J.A., Vogel H.J. (2000) Spectroscopic characterization of the interaction between calmodulin-dependent protein kinase I and calmodulin. Arch Biochem Biophys. 379, 28-36.

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Cuervo A.M., Gomes A.V., Barnes J.A., Dice J.F. (2000) Selective Degradation of Annexins by Chaperone-mediated Autophagy. J. Biol. Chem. 275, 33329-33335.